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Antimicrob Agents Chemother. 1995 Jul;39(7):1629-31.

The renal membrane dipeptidase (dehydropeptidase I) inhibitor, cilastatin, inhibits the bacterial metallo-beta-lactamase enzyme CphA.

Author information

1
Department of Biochemistry and Molecular Biology, University of Leeds, United Kingdom.

Abstract

The Aeromonas hydrophila AE036 chromosome contains a cphA gene encoding a metallo-beta-lactamase which is highly active against carbapenem antibiotics such as imipenem. Here we show that the cphA gene product shares inhibitory similarities with a mammalian zinc peptidase, membrane dipeptidase (MDP; dehydropeptidase I). Both enzymes are able to hydrolyze imipenem and are inhibited by cilastatin. The active site similarities of these enzymes are not reflected in any significant primary sequence similarity.

PMID:
7492120
PMCID:
PMC162797
DOI:
10.1128/aac.39.7.1629
[Indexed for MEDLINE]
Free PMC Article

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