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J Urol. 1996 Jan;155(1):26-9.

Therapy of locally recurrent renal cell carcinoma after nephrectomy.

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1
Department of Urology, University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.

Abstract

PURPOSE:

We evaluated the outcome of patients with locally recurrent renal cell carcinoma treated at our university.

MATERIALS AND METHODS:

We retrospectively analyzed 16 cases of locally recurrent renal cell carcinoma in the renal fossa treated with surgical resection alone or in combination with biological therapy.

RESULTS:

Complete resection was possible in 15 patients of whom 3 had positive surgical margins. Of the 12 patients with negative margins 6 are free of disease while the 3 with positive margins had involvement of a remaining ipsilateral adrenal gland and distant metastasis. Of all 16 patients 12 are alive a median of 23.5 months after the diagnosis of locally recurrent renal cell carcinoma. Of those treated with the combination of biological therapy and surgery 50% have no evidence of disease compared to 25% of those treated with surgery alone.

CONCLUSIONS:

Long-term survival can be achieved with an aggressive surgical approach. Incomplete resection or positive surgical margins are associated with a high risk of local or distant failure, and combined treatment with immunotherapy and surgery may offer a benefit compared to surgery alone.

PMID:
7490850
[Indexed for MEDLINE]
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