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J Am Acad Dermatol. 1995 Dec;33(6):969-72.

Improvement of skin barrier function during treatment of atopic dermatitis.

Author information

1
Department of Dermatology, University Central Hospital, Helsinki, Finland.

Abstract

BACKGROUND:

Active dermatitis causes a disturbance in skin barrier function. This can be evaluated by the measurement of transepidermal water loss (TEWL) and percutaneous absorption of hydrocortisone.

OBJECTIVE:

The study objective was to evaluate changes in skin barrier function during treatment of atopic dermatitis.

METHODS:

Nine patients with widespread atopic dermatitis were studied longitudinally by measuring the severity of the dermatitis and TEWL at intervals of 1 to 3 days. Percutaneous absorption of hydrocortisone was measured at entry and during treatment.

RESULTS:

At entry, both TEWL and percutaneous absorption of hydrocortisone were elevated. Four to six days later, a significant decline was observed in both variables, indicating rapid improvement in skin barrier function. Individual changes in TEWL correlated with the changes in the systemic absorption of hydrocortisone.

CONCLUSION:

TEWL reflects changes in the systemic absorption of topical hydrocortisone during treatment of atopic dermatitis.

PMID:
7490367
DOI:
10.1016/0190-9622(95)90288-0
[Indexed for MEDLINE]

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