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Genomics. 1995 Aug 10;28(3):576-80.

Chromosomal localization, embryonic expression, and imprinting tests for Bmp7 on distal mouse chromosome 2.

Author information

1
Department of Developmental Biology, Beckman Center, Stanford University School of Medicine, California 94305-5427, USA.

Abstract

Murine Bmp7 has been assigned to distal Chromosome 2 by interspecific backcross mapping. The map location suggests close linkage to classical mouse mutations and places Bmp7 within a chromosome region thought to contain one or more unidentified imprinted genes. A direct test suggests that Bmp7 is not imprinted. An examination of embryonic RNA expression patterns shows that Bmp7 is expressed in a variety of skeletal and nonskeletal tissues. Both embryonic expression patterns and the human chromosomal sublocalization inferred from its mouse location make Bmp7 a candidate for the gene affected in some patients with Holt-Oram syndrome.

PMID:
7490098
DOI:
10.1006/geno.1995.1192
[Indexed for MEDLINE]

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