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Eur J Immunol. 1995 Nov;25(11):3115-22.

Efficient immune responses in mice lacking N-region diversity.

Author information

1
Institut de Génétique et de Biologie Moléculaire et Cellulaire, (INSERM/CNRD/ULP) Illkirch, C. U. de Strasbourg, France.

Abstract

Mice with a null mutation in the terminal deoxynucleotidyl transferase (TdT) gene harbor immunoglobulin and T cell receptor repertoires essentially devoid of N-region diversity. Consequently, the CDR3 loops important for antigen recognition are shorter and considerably less diverse than those of wild-type controls. We find surprisingly normal immune responses in TdT0 mice, as regards both efficiency and specificity. This provokes a reconsideration of the assumption that N-region diversity is required for an effective T and B cell repertoire.

PMID:
7489751
DOI:
10.1002/eji.1830251119
[Indexed for MEDLINE]

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