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Eur J Vasc Endovasc Surg. 1995 Nov;10(4):459-65.

Outcome and quality of life of patients with severe chronic limb ischaemia: a cohort study on the influence of diabetes.

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1
Department of Surgery, University of São Paulo School of Medicine, Brazil.

Abstract

OBJECTIVE:

To determine the influence of diabetes on the use of arterial reconstruction, the rate of amputation and death, and the quality of life of patients with severe limb ischaemia.

DESIGN:

A prospective study of patients with the first episode of ischaemia.

SETTING:

University tertiary referral centre.

METHODS:

Thirty-seven patients with diabetes and 50 without diabetes, were studied over a 12 month period with complete follow-up.

MAIN OUTCOME MEASURES:

The proportion of patients undergoing an arterial reconstruction, amputation rate, death rate, and quality-of-life scores.

RESULTS:

Patients with diabetes underwent an arterial reconstruction less often than patients without diabetes (7/37 vs. 18/50). The odds of patients with diabetes having a higher incidence of adverse outcome was 1666:1 for minor amputation, 26:1 for major amputation, and 4.7:1 for death. There was a tendency towards a lower quality of life for patients with diabetes at 3 (OR 1.94, p = 0.036), 6 (OR 1.58, p = 0.117), and 12 (OR 1.47, p = 0.185) months.

CONCLUSIONS:

In patients with diabetes, (1) the opportunity of undergoing an arterial reconstruction is lower, (2) morbidity and mortality are higher, and (3) the quality of life tends to be worse.

PMID:
7489215
[Indexed for MEDLINE]
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