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Am J Psychiatry. 1995 Nov;152(11):1668-71.

Acute tryptophan depletion and increased food intake and irritability in bulimia nervosa.

Author information

1
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, USA.

Abstract

OBJECTIVE:

Data suggest that serotonin activity is reduced in women at normal weight who have bulimia nervosa. The authors tested whether acute perturbations in serotonin activity could alter short-term eating behavior and mood.

METHOD:

They examined the effect of acute tryptophan depletion in 10 women with and 10 women without bulimia nervosa.

RESULTS:

Women with bulimia nervosa exhibited an increase in caloric intake and mood irritability after acute tryptophan depletion.

CONCLUSIONS:

These results indicate that women with bulimia nervosa have an exaggerated or pathological response to transient alterations in serotonin activity.

PMID:
7485633
DOI:
10.1176/ajp.152.11.1668
[Indexed for MEDLINE]

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