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Trends Pharmacol Sci. 1995 Sep;16(9):317-21.

Implications of prolonged expression of Fos-related antigens.

Author information

1
Department of Pharmacology and Therapeutics, University of South Florida, Tampa 33612-4799, USA.

Abstract

The AP-1 transcription factors are composed of the Fos and Fos-related antigens as well as Jun and related proteins. These factors have been extensively studied in many diverse paradigms using acute stimuli. Recent attention has focussed on long-term elevation of Fos-related antigens in the CNS, and this is discussed by Keith Pennypacker, Jau-S. Hong and Michael McMillian. Repeated or chronic treatment elevates Fos-related antigen levels for days in many different brain regions. Both direct and indirect stimulation are responsible for the protracted increase in Fos-related antigen-immunoreactive proteins, which may modulate late onset genes involved in neuroplasticity. Understanding the role of these factors in long-lasting or permanent disease states may provide insight into potential therapeutic strategies to treat chronic CNS disorders.

PMID:
7482997
DOI:
10.1016/s0165-6147(00)89061-6
[Indexed for MEDLINE]

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