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Trends Genet. 1995 Oct;11(10):388-92.

What to do at an end: DNA double-strand-break repair.

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Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, MA, USA.


Repairing chromosome breaks is essential to cell survival. A major lethal effect of ionizing radiation (IR) damage is the creation of double-strand DNA breaks. Recently, a number of mammalian cell mutants that are sensitive to IR damage have been described, revealing a unique repair pathway. The DNA-dependent protein kinase (DNA-PK) is necessary for double-strand-break repair and lymphoid V(D)J recombination. DNA-PK consists of three subunits: the Ku autoantigen heterodimer and a kinase (DNA-PKCS) that is deficient in mouse scid mutant cells.

[Indexed for MEDLINE]

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