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Trends Biochem Sci. 1995 Sep;20(9):367-71.

GPI-anchor biosynthesis.

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1
Department of Immunoregulation, Osaka University, Japan.

Abstract

Many eukaryotic proteins bind to membranes using a glycosylphosphatidylinositol (GPI) anchor. GPI anchors are essential in yeasts and probably also in protozoa. Although mammalian cells can survive without GPI anchors, their deficiency in haemopoietic cells cause a haemolytic disease, paroxysmal nocturnal haemoglobinuria (PNH). Here, we discuss recent progress in our understanding of GPI-anchor biosynthesis that could lead to a better understanding of PNH and chemotherapeutic agents to treat protozoal and fungal infections.

PMID:
7482705
[Indexed for MEDLINE]
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