Format

Send to

Choose Destination
Radiology. 1995 Nov;197(2):517-23.

H-1 MR spectroscopic imaging of white matter signal hyperintensities: Alzheimer disease and ischemic vascular dementia.

Author information

1
Magnetic Resonance Spectroscopy Unit, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA.

Abstract

PURPOSE:

To investigate the association of white matter signal hyperintensities (WMSHs) with changes in hydrogen-1 metabolites.

MATERIALS AND METHODS:

T2-weighted magnetic resonance (MR) imaging and H-1 MR spectroscopic imaging were performed in 21 elderly control subjects without or with minimal WMSHs, eight elderly subjects with substantial WMSHs, 11 probable Alzheimer disease patients with WMSHs, and eight ischemic vascular dementia (IVD) patients with WMSHs. N-acetylaspartate (NAA), choline-containing metabolites (Cho), and creatine-containing metabolites (Cr) were analyzed.

RESULTS:

Differences in regional metabolite levels were found within the supraventricular brain of elderly control subjects. In Alzheimer disease patients, extensive WMSHs showed a lower percentage of NAA and a higher percentage of Cho compared with contralateral normal-appearing white matter (NAWM); in IVD patients, extensive and large WMSHs were associated with a higher percentage of Cho and a lower percentage of Cr compared with contralateral NAWM.

CONCLUSION:

Regional metabolite variation and the presence of WMSHs are important covariants that must be accounted for in analysis of MR spectroscopic data.

PMID:
7480705
PMCID:
PMC2780019
DOI:
10.1148/radiology.197.2.7480705
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Atypon Icon for PubMed Central
Loading ...
Support Center