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Prog Lipid Res. 1995;34(2):139-50.

The regulation of stearoyl-CoA desaturase (SCD).

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Department of Biochemistry and Nutritional Sciences, University of Wisconsin-Madison 53706, USA.


The stearoyl-CoA desaturase gene family encodes stearoyl-CoA desaturase, the key enzyme involved in the biosynthesis of unsaturated fatty acids, as well as in the regulation of this process. Because of the important role that the SCD gene product plays in fat cell metabolism, future studies on SCD1 gene expression could provide new insights into the role of fatty acids in cellular regulation, metabolism, and gene expression both in normal and disease states. In addition, the SCD gene family can be used as a model to study mechanisms of cellular differentiation, tissue-specific gene expression, and dietary and hormonal regulation of gene expression.

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