Radial scar versus tubular carcinoma of the breast. A comparative study with quantitative techniques (morphometry, image- and flow cytometry)

Pathol Res Pract. 1995 Jul;191(6):547-54. doi: 10.1016/S0344-0338(11)80875-7.

Abstract

The present study is focused on the differential diagnosis between radial scar (RS) and tubular carcinoma (TC) using morphometrical and cytophotometrical analysis (static and flow cytometry) of a number of histologically well-established RS cases (17 lesions) compared with 6 early infiltrating small TC with sclerotic stroma and pseudo-RS fields. One case displayed both RS and TC foci in contiguity. Mean nuclear area was larger in the group of tubular carcinomas (51.0 mu 2) than in the case of radial sclerosis (38.30 mu 2). We also found a larger number of aneuploid cases in tubular carcinomas measured by image cytometry, but both types of lesions were diploid when measured by flow cytometry; only one case of radial scar resulted aneuploid.

Publication types

  • Comparative Study

MeSH terms

  • Adenocarcinoma / genetics
  • Adenocarcinoma / pathology*
  • Breast / pathology*
  • Breast Neoplasms / genetics
  • Breast Neoplasms / pathology*
  • DNA / genetics
  • Diagnosis, Differential
  • Female
  • Flow Cytometry
  • Humans
  • Ploidies
  • Sclerosis

Substances

  • DNA