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Nature. 1995 Nov 16;378(6554):245-8.

The enigma of the natural killer cell.

Author information

1
Department of Structural Biology and Microbiology, Stanford University, California 94305, USA.

Abstract

Natural killer (NK) cells are controlled by receptors specific for polymorphic determinants of class I molecules of the major histocompatibility complex (MHC). The contrasting properties of NK and cytotoxic T cell (CTL) class I receptors provide complementarity in the cytolytic lymphocyte response to viruses, tumours and transplants. Whereas human NK cell class I receptors consist of immunoglobulin domains, their mouse counterparts resemble C-type lectins. This difference may reflect the receptors' diverse and rapidly evolving class I ligands.

PMID:
7477341
DOI:
10.1038/378245a0
[Indexed for MEDLINE]

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