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Nature. 1995 Nov 9;378(6553):150-7.

A homeobox gene essential for zebrafish notochord development.

Author information

1
Institute of Neuroscience, University of Oregon, Eugene 97403, USA.

Abstract

The notochord is a midline mesodermal structure with an essential patterning function in all vertebrate embryos. Zebrafish floating head (flh) mutants lack a notochord, but develop with prechordal plate and other mesodermal derivatives, indicating that flh functions specifically in notochord development. We show that floating head is the zebrafish homologue of Xnot, a homeobox gene expressed in the amphibian organizer and notochord. We propose that flh regulates notochord precursor cell fate.

PMID:
7477317
DOI:
10.1038/378150a0
[Indexed for MEDLINE]

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