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Nature. 1995 Oct 26;377(6551):695-701.

Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein.

Author information

1
Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

Abstract

The gene encoding p120-rasGAP, a negative regulator of Ras, has been disrupted in mice. This Gap mutation affects the ability of endothelial cells to organize into a highly vascularized network and results in extensive neuronal cell death. Mutati ons in the Gap and Nf1 genes have a synergistic effect, such that embryos homozygous for mutations in both genes show an exacerbated Gap phenotype. Thus rasGAP and neurofibromin act together to regulate Ras activity during embryonic development.

PMID:
7477259
DOI:
10.1038/377695a0
[Indexed for MEDLINE]

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