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Br J Anaesth. 1981 Jan;53(1):27-30.

Pharmacokinetics and analgesic effect of ketamine in man.

Abstract

The pharmacokinetics and analgesic effect of i.v. ketamine in doses of 125 microgram kg-1 and 250 microgram kg-1 were determined in five healthy volunteers. Analgesia was measured with the submaximal effort tourniquet test. Both doses of ketamine prolonged the period of pain-free ischaemic exercise while the plasma ketamine concentration was greater than 100 ng ml-1. Ketamine was distributed rapidly (T 1/2 alpha = 17 min). The elimination half-life was 186 min.

PMID:
7459184
DOI:
10.1093/bja/53.1.27
[Indexed for MEDLINE]
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