Abstract
The title diphenol, 1a, was synthesized from p,p'-dihydroxy-alpha-truxillic acid and shown to be active as an oral postcoital antifertility agent in rats: ED100 = 100 (micrograms/kg)/day. The oral uterotropic potency was estimated to be 16% of that of diethylstilbestrol (95% confidence limits of potency 8--35%). The structure of the diphenol, 1a, was confirmed by single-crystal X-ray analysis of the dimethyl ether.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antineoplastic Agents
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Chemical Phenomena
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Chemistry
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Contraceptives, Postcoital / chemical synthesis*
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Contraceptives, Postcoital, Synthetic / chemical synthesis*
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Female
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Male
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Naphthols / chemical synthesis*
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Naphthols / pharmacology
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Organ Size / drug effects
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Rats
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Uterus / drug effects
Substances
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Antineoplastic Agents
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Contraceptives, Postcoital
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Contraceptives, Postcoital, Synthetic
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Naphthols
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3,9-dihydroxyoctahydrodibenzo(a,g)biphenylene