Stimulation of bile and pancreatic secretion by duodenal perfusion with Na-taurocholate in the cat compared with jejunal and ileal perfusion

Scand J Gastroenterol. 1980;15(4):433-42. doi: 10.3109/00365528009181496.

Abstract

In the anesthetized cat duodenal perfusion with Na-taurocholate (TC, 0.2 M, pH 6.1, 290 mosmol, 45 ml x h-1) stimulated pancreatic volume (0 to 326 +/- 236 mg x 10 min-1) and bicarbonate secretion (0 to 34.2 +/- 4.1 mumol x 10 min-1), whereas pancreatic enzyme output was sparse. Simultaneously with the pancreatic response, bile flow increased from 139 +/- 74 mg to 484 +/- 146 mg x 15 min-1 (p < 0.05). During perfusion of the upper jejunum both pancreatic and biliary responses were significantly lower than the responses to duodenal TC perfusion (p < 0.05). During TC perfusion of the terminal ileum there was no response from the pancreas, whereas the increase in bile flow accounted only for an increase in the bile-acid-dependent fraction. The concomitant stimulation of both the hydrokinetic function of the pancreas and the bile-acid-independent bile flow might be mediated by a release of secretin.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bile / metabolism*
  • Bile Acids and Salts / metabolism
  • Cats
  • Duodenum
  • Female
  • Ileum
  • Jejunum
  • Pancreas / metabolism*
  • Pancreatic Juice / metabolism
  • Perfusion
  • Secretory Rate / drug effects
  • Taurocholic Acid / administration & dosage
  • Taurocholic Acid / pharmacology*

Substances

  • Bile Acids and Salts
  • Taurocholic Acid