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Br J Cancer. 1980 Jun;41(6):886-91.

Dependence of the cytostatic effect of adriamycin on drug concenration and exposure time in vitro.

Abstract

The surviving fraction (SF) of Chinese hamster cells and HeLa cells after treatment with a range of Adriamycin concentrations and exposure times was determined. The cytostatic effect was proportional to the product of extracellular drug concentration (c) and exposure time (t) according to the equation: SF=e-ktc. By determining the intracellular drug concentration at various exposures, it could be shown that absorbed dose is not proportional to exposure dose.

PMID:
7426313
PMCID:
PMC2010346
DOI:
10.1038/bjc.1980.165
[Indexed for MEDLINE]
Free PMC Article

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