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Experientia. 1980 Oct 15;36(10):1217-9.

Phospholipase C-induced neural tube defects in the mouse embryo.

Abstract

Mouse embryo neurulae were exposed in vitro to phospholipase C to examine the role of carbohydrate-rich extracellular material (ECM) during neurulation. Exposure of embryos to this agent for 12 h resulted in failure of closure of the neural tube. Ultrastructural examination revealed an absence of ECM from regions of the neural tube which failed to close.

PMID:
7418810
DOI:
10.1007/bf01976138
[Indexed for MEDLINE]

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