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Fertil Steril. 1980 Jul;34(1):32-5.

Serum copper in long-term users of copper intrauterine devices.

Abstract

A study was undertaken to determine whether long-term use of a copper intrauterine device (IUD) was associated with any alteration in the serum copper levels and thereby whether absorption of copper from the device in utero could result in copper toxicity. Serial estimations in copper IUD wearers showed that there was no alteration in serum copper levels for a period of up to 24 months. The mean range and frequency distribution of serum copper levels in long-term copper IUD wearers was similar to that seen in the normal population. There was no difference in the mean 24-hour urinary copper excretion between the control group and the copper IUD wearers. Data suggest that the copper released from a copper IUD may not be readily absorbed from the uterine fluid. This hypothesis needs verification.

PIP:

This study was performed to determine whether long-term use of copper IUDs was associated with any alteration in serum copper levels in users. These studies had both cross-sectional and longitudinal components, with the cross-sectional aspect covering 148 controls and 202 women who used either the Lippes loop (n=95) or the copper T 200 (n=107) for 6-48 months. The longitudinal aspect was carried out in 7 women not using any form of contraception and in 17 women who had had a copper IUD inserted; serial copper levels in serum were measured every 3 months for 24 months. The aim was to ascertain any danger of copper toxicity with copper-medicated IUD use. Serial estimations in copper IUD wearers showed that there was no alteration in serum copper levels for up to 24 months. The mean range and frequency distribution of serum copper levels in long-term copper IUD wearers were similar to those seen in the normal (control) population. In addition, there was no difference in the mean 24-hour urinary copper excretion between the control group and copper IUD users. The results verified the first hypothesis of the researchers, that copper released from a copper IUD is not readily absorbed.

PMID:
7398904
[Indexed for MEDLINE]

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