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J Med Chem. 1980 Jun;23(6):682-4.

Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability.

Abstract

The rat brain capillary permeability coefficient was determined for 27 compounds. The relationship of permeability to octanol/water partition coefficient and molecular weight was found to be predictable for drugs with molecular weights less than 400.

PMID:
7392035
DOI:
10.1021/jm00180a022
[Indexed for MEDLINE]

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