Abstract
Peripheral-blood lymphocytes from patients with coeliac disease showed a marked increase in D.N.A. synthesis after incubation in vitro with a subfraction of gluten. Lymphocytes from control patients showed no increased D.N.A. synthesis under the same conditions. The possible use of this specific lymphocyte-stimulation assay as a screening test for coeliac disease is discussed.
MeSH terms
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Adolescent
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Adult
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Aged
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Atrophy
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Celiac Disease / blood
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Celiac Disease / etiology*
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Cells, Cultured
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DNA / biosynthesis
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Female
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Glutens / toxicity*
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Humans
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Hypersensitivity, Immediate / complications
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Hypersensitivity, Immediate / diagnosis*
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In Vitro Techniques
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Jejunum / pathology
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Lymphocytes / immunology*
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Lymphocytes / metabolism
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Male
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Middle Aged
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Stimulation, Chemical
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Time Factors