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Boll Soc Ital Biol Sper. 1980 Mar 30;56(6):563-8.

[Action of free fatty acids on platelet aggregation induced with thrombin].

[Article in Italian]


The sinergic effect on thrombin-induced platelet aggregation by Free Fatty Acids (FFA) was studied "in vitro". Our results showed that "sub-critical" concentrations of long carbon chains of saturated and unsaturated FFA potentiated the platelet aggregation induced by "critical" concentration of thrombin. However, we suggest that: a) exogenous long carbon chains of FFA could enhance the platelet membrane lipids and increase the ciclic Endoperoxides, Prostaglandins and Thromboxan A2 synthesis; b) exogenous long carbon chains of FFA could induce the platelets more "sensitive" to aggregating effect of "critical" concentrations of thrombin.

[Indexed for MEDLINE]

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