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Toxicol Lett. 1980 Jan;5(1):69-75.

Enhancement of toxicity and enzyme-repressing activity of p-dioxane by chlorination: stereoselective effects.

Abstract

The acute toxicity of p-dioxane may be enhanced up to 1000-fold by chlorination of the compound. The effect was stereoselective. Of the stereoisomers tested, tetrachloro-p-dioxane, isomer I (2r, 3t, 5t, 6c) was over 80 times more toxic than isomer II (2r, 3c, 5t, 6t). The latter compound was also a potent repressor of hepatic dimethylnitrosamine-demethylase I (DMN-d) and aryl hydrocarbon hydroxylase (AHH).

PMID:
7376202
[Indexed for MEDLINE]
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