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Brain Res. 1980 Jan 20;182(1):157-66.

Central and peripheral actions of amphetamine on memory storage.

Abstract

These experiments investigated the effects of central (intracerebroventricular) and peripheral (i.p.) posttraining administration of D-amphetamine on rat's retention of a one-trial inhibitory avoidance response. While retention was enhanced by i.p. administration (1.0 mg/kg) the central administration (dose range 50-500 microgram) did not affect retention. In rats given peripheral 6-OHDA 24 h prior to training a lower dose (i.p.) of amphetamine (0.25 mg/kg) was most effective in enhancing retention. These findings suggest that the mrmory enhancing effects of D-amphetamine are mediated at least in part through peripheral systems.

PMID:
7350983
DOI:
10.1016/0006-8993(80)90838-0
[Indexed for MEDLINE]

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