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J Antibiot (Tokyo). 1981 Sep;34(9):1090-100.

Studies on a new aminoglycoside antibiotic, dactimicin. II. Isolation, structure and chemical degradation.

Abstract

A new aminoglycoside antibiotic, dactimicin produced by a Dactylosporangium matsuzakiense SF-2052 has been isolated by column chromatography on a cation-exchange resin and CM-sephadex. The structure of dactimicin was determined to be 4-amino-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo- heptopyranosyl)-1-[(N-formimidoylglycyl)-methylamino]-6-O-methyl-L-chiro-inosit ol. Alkaline hydrolysis of dactimicin afforded 1-N-(N-formylglycyl)fortimicin B, fortimicin B, fortimicin A and an acyl migration product, 2'-N-(N-formylglycyl)fortimicin B.

PMID:
7328051
DOI:
10.7164/antibiotics.34.1090
[Indexed for MEDLINE]
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