The formation of N-nitrosomethyl(2-oxopropyl)amine from N-nitrosobis(2-oxopropyl)amine in vivo

Carcinogenesis. 1981;2(9):845-9. doi: 10.1093/carcin/2.9.845.

Abstract

After injection of N-nitrosobis(2-oxopropyl)amine (BOP) (10 mg/kg) to male Syrian golden hamsters there were there concentrations of BOP and many of its metabolites in the hamster pancreas compared with the liver and salivary gland. Also, a potential methylating metabolite of BOP, N-nitrosomethyl(2-oxopropyl)amine, was found in both tissues.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Biotransformation
  • Carcinogens / metabolism*
  • Chromatography, Gas
  • Cricetinae
  • Male
  • Mesocricetus
  • Nitrosamines / metabolism*
  • Tissue Distribution

Substances

  • Carcinogens
  • Nitrosamines
  • N-nitrosomethyl-2-oxopropylamine
  • nitrosobis(2-oxopropyl)amine