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Am J Hum Genet. 1981 Sep;33(5):683-91.

Origin of the triosephosphate isomerase isozymes in humans: genetic evidence for the expression of a single structural locus.


A genetic approach is used to ascertain that a single structural locus for triosephosphate isomerase (TPI) (E.C. is expressed in rapidly dividing human lymphoblasts. This approach is made possible through the identification of a rare electrophoretic variant of human TPI. The variant phenotype is expressed by the TPI-B isozyme in both erythrocytes and peripheral lymphocytes. The variant phenotype is also expressed in the thermostability and electrophoretic pattern of the TPI-A isozyme in mitogen-stimulated lymphoblasts, indicating that TPI-A and TPI-B are products of the same structural locus. These findings are in contrast to the recent conclusions of Yuan et al. based upon structural analysis, suggesting that the TPI-A and TPI-B isozymes are products of distinct structural loci.

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