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Eur J Clin Pharmacol. 1981;20(6):479-83.

Pharmacokinetic study of chloramphenicol in patients with liver disease.

Abstract

The pharmacokinetics of intravenous chloramphenicol has been studied in 42 patients with liver disease and in 8 controls. The half-life of chloramphenicol (t 1/2) was increased in the various liver disorders, the metabolic clearance rate (MCR) and apparent volume of distribution (Vd) were decreased and the area under the time - concentrations curve (AUC) showed an increase. The t 1/2 of chloramphenicol showed a significant correlation with serum albumin and prothrombin time index.

PMID:
7286060
DOI:
10.1007/bf00542103
[Indexed for MEDLINE]

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