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Ann Neurol. 1981 Aug;10(2):122-6.

Alzheimer disease: evidence for selective loss of cholinergic neurons in the nucleus basalis.

Abstract

The nucleus basalis of Meynert provides diffuse cholinergic input to the neocortex. When compared with an age- and sex-matched control, the nucleus basalis from a patient with Alzheimer disease demonstrated substantial reduction of neurons. Loss of this neuronal population may represent an anatomical correlate of the well-documented cholinergic derangement in Alzheimer disease.

PMID:
7283399
DOI:
10.1002/ana.410100203
[Indexed for MEDLINE]
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