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Neurosci Lett. 1981 Jul 17;24(3):289-94.

M-Currents in voltage-clamped mammalian sympathetic neurones.

Abstract

The M-current (IM), a species of time- and voltage-dependent K+-current previously identified in amphibian sympathetic neurones, has been detected in voltage-clamped rat sympathetic neurone somata. IM had an activation threshold of about -70 mV and, since it did not show time-dependent inactivation, contributed an increasing outward component to the steady membrane current between -70 and -20 mV. Selective inhibition of IM by muscarine or by angiotensin-II probably accounts for the membrane depolarization produced by these two agonists on rat ganglia.

PMID:
7279296
DOI:
10.1016/0304-3940(81)90173-7
[Indexed for MEDLINE]

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