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Am Rev Respir Dis. 1981 Jun;123(6):689-90.

Tissue distribution of [14C]ethambutol in mice.

Abstract

Fifteen male mice were given oral doses of 32 mg [14C]ethambutol/kg in a study of the tissue distribution of the drug. Animals were killed 1, 2, 4, 7, and 24 h after dosage and radioactivity in various tissues was measured. Peak concentrations were seen at 2 h after dosage. With the exception of brain, all tissues examined (liver, kidney, heart, spleen, lung, and muscle) developed tissue-to-plasma concentration ratios greater than 2. Highest values were seen in liver, kidney, and lung. High lung values were viewed as a favorable attribute for a drug used in the treatment of tuberculosis.

PMID:
7271070
DOI:
10.1164/arrd.1981.123.6.689
[Indexed for MEDLINE]

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