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Brain Res. 1981 Feb 16;206(2):479-84.

Role of intracortical inhibition in deprivation amblyopia: reversal by microiontophoretic bicuculline.


The GABA antagonist, bicuculline, was microiontophoretically applied to 31 cells in the visual cortices of 4 cats monocularly deprived of vision from birth to time of study at age 5 months. Bicuculline restored input from the deprived eye to 42% of cells studied. Elevation of background firing rates by glutamate failed to restore deprived eye input. We suggest that intracortical inhibition plays an important role in maintaining the physiological abnormalities produced in visual cortex by monocular deprivation.

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