[Enzyme characteristics of the rat liver in ontogeny in chronic alcohol intoxication]

Vopr Med Khim. 1982 Jul-Aug;28(4):96-101.
[Article in Russian]

Abstract

Chronic alcohol intoxication led to an increase in activity of alcohol dehydrogenase and to decrease -- of aldehyde dehydrogenase and the microsomal ethanol oxidizing system (MEOS) with simultaneous activation of cytochrome P-450 in liver tissue of rats during ontogenesis. Ethanol, which did not affect the enzymatic status of lysosomes within ontogenesis (alpha- and beta-glucosidases, alpha- and beta-galactosidases, alpha-mannosidase, beta-N-acetylglucosaminidase, beta-xylosidase, beta-glucuronidase, beta-N-acetyl galactosaminidase acid RNAase, arylsulfatases A and B, cathepsin D), activated the majority of hydrolases in both embryonal and postnatal periods of development. Distinct increase in lipoperoxidation was detected under conditions of chronic alcohol intoxication.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Alcoholism / enzymology*
  • Animals
  • Female
  • Humans
  • Kinetics
  • Liver / drug effects
  • Liver / enzymology*
  • Liver / growth & development
  • Lysosomes / enzymology
  • Male
  • Rats
  • Rats, Inbred Strains
  • Time Factors