The effect of gamma irradiation of human cells and somatic cell hybridization on sister chromatid exchange frequencies in the hamster chromosomes of hamster-human hybrid lines

Cytogenet Cell Genet. 1981;30(3):146-51. doi: 10.1159/000131602.

Abstract

Sister chromatid exchange (SCE) frequency was studied in human/hamster hybrid lines in which the human cells had been exposed to gamma irradiation at doses of 0, 10, 20, and 40 grays. A higher SCE frequency was found in the hamster chromosomes in the hybrid lines than was found in the hamster parental cell line CHW1103. There was also a dose-dependent increase of SCE frequency in the unirradiated hamster chromosomes in the hybrid lines in which the human parental cells had been irradiated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Fusion / radiation effects
  • Cell Line
  • Chromosomes / radiation effects*
  • Cricetinae
  • Cricetulus
  • Crossing Over, Genetic*
  • Dose-Response Relationship, Radiation
  • Female
  • Gamma Rays
  • Humans
  • Hybrid Cells / radiation effects*
  • Ovary
  • Sister Chromatid Exchange*