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Hum Pathol. 1981 May;12(5):472-4.

Precursor stage of hepatocellular neoplasm following long exposure to orally administered contraceptives.

Abstract

Hepatic neoplasms and peliosis are known to occur in women taking contraceptives orally. We observed hyperplasia of hepatocytes combined with hypertrophy of sinusoidal lining cells and sinusoidal dilatation with progression to peliosis in the liver of a patient who had been taking such contraceptives for 10 years. These changes resembled the precursor stage in the development of hepatic angiosarcoma induced by vinyl chloride, Thorotrast, and arsenic. In users of orally administered contraceptives these findings may precede the development of hepatocellular neoplasms.

PIP:

A case report of a 32-year-old patient who had been taking OCs (oral contraceptives) for 10 years is summarized. Microscopic photographs taken at the biopsy are presented and discussed. Hyperplasia of hepatocytes combined with hypertrophy of sinusoidal lining cells and sinusoidal dilatation with progression to peliosis in the liver were found at biopsy. These changes resemble the precursor stage of hepatocellular neoplasm. Although most of the tumors associated with OCs are benign, they may represent a serious threat to the patient, since they can rupture spontaneously, resulting in intra-abdominal hemorrhage. Women using OCs should be carefully monitored in order to detect the changes described in this report or actual hepatic tumors. Discontinuation of the OCs may reverse the development of the hepatic changes.

PMID:
7195872
[Indexed for MEDLINE]

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