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J Clin Endocrinol Metab. 1980 Sep;51(3):611-5.

Biological properties of 16 alpha-hydroxyestrone: implications in estrogen physiology and pathophysiology.

Abstract

Metabolism of estradiol in men with cirrhosis and subjects with systemic lupus erythematosus results in an excessive formation of 16 alpha-hydroxyestrone. Examination of the biological activity of this metabolite showed that it is a potent uterotropic agent and that it exhibits minimal affinity for the human sex hormone-binding globulin. These biological characteristics are consistent with a hyperestrongenic response to the substance, which may be reflected in the pathology and etiology of these diseases.

PMID:
7190977
DOI:
10.1210/jcem-51-3-611
[Indexed for MEDLINE]

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