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Brain Res. 1982 Jan 28;232(2):479-84.

Cholinergic agonist-induced down regulation of neuronal alpha-bungarotoxin receptors.

Abstract

The ability of cholinergic ligands to regulate neuronal alpha-bungarotoxin receptor number was studied in dissociated monolayer cultures of embryonic chick ciliary ganglion neurons. Carbamylcholine and nicotine, but not D-tubocurarine, caused a loss of 25% of the surface [125I]alpha-bungarotoxin receptors within 1 h at 37 degrees C. This receptor loss occurred without change in affinity for [125I]alpha-bungarotoxin, was temperature-sensitive and was prevented by co-incubation with D-tubocurarine.

PMID:
7188033
DOI:
10.1016/0006-8993(82)90292-x
[Indexed for MEDLINE]

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