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J Med Microbiol. 1982 Nov;15(4):493-501.

Immunogenicity of leptospiral vaccines grown in protein-free medium.

Abstract

Leptospira interrogans serovars pomona and hardjo were adapted to grow in a chemically-defined, protein-free (PF) medium. Formolised monovalent vaccines of serovars pomona and hardjo and a bivalent mixture of the two were prepared from PF cultures. Live PF cultures and the vaccine preparations retained their agglutinating antigens and their immunogenicity when tested in rabbits and guinea-pigs. The vaccines were not pyrogenic and dermal reactions were slight.

PMID:
7175917
DOI:
10.1099/00222615-15-4-493
[Indexed for MEDLINE]

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