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Gen Pharmacol. 1982;13(5):453-6.

Flurazepam effects on rat cerebellar Purkinje cells.


1. Cerebellar Purkinje cell activity was recorded in urethane anaesthetized rats. 2. Flurazepam, infused intravenously in divided doses totalling 4 mg/kg, decreased simple spike activity, increased complex spike activity and prolonged local surface inhibition. 3. Iontophoretically applied flurazepam enhanced the effect of GABA and elicited a bursting pattern of discharge when released using larger currents for ejection.

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