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Eur J Drug Metab Pharmacokinet. 1982 Oct-Dec;7(4):293-8.

The metabolism of nicotine-delta 1'(5')-iminium ion, in vivo and in vitro.

Abstract

Nicotine-delta 1'(5')-iminium ion, either as the diperchlorate or the hydrochloride, is rapidly converted into cotinine by a hepatic cytoplasmic enzyme. Incubations in an atmosphere of nitrogen indicated that the oxygen incorporated into cotinine is derived from water. Following the intraperitoneal administration of nicotine-delta 1'(5')-iminium ion to guinea pigs or rats, cotinine, and nicotine-1'-N-oxide were found in the urine. The results support the idea that nicotine-delta 1'-(5')-iminium ion is an intermediate in the metabolic conversion of nicotine to cotinine.

PMID:
7166181
DOI:
10.1007/BF03189632
[Indexed for MEDLINE]

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