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Modification of liver microsomal lipids by halothane metabolites; a multi nuclear NMR spectroscopic study.

Abstract

N-trifluoroacetyl phosphatidyl ethanolamine was found as an intermediate of biotransformation of halothane after intense in vivo exposure of non-induced and phenobarbital induced rabbits. The metabolite has been identified in detergent treated liver microsomes by 31P-NMR-spectroscopy and in microsomal lipid extracts by 19F-NMR- and 1H-NMR-spectroscopy as well as by thin layer chromatography. The same exposure changed phospholipid composition of liver microsomal membranes: most prominent was a substantial decrease of the ratio of phosphatidyl ethanolamines to phosphatidylcholines.

PMID:
7155205
DOI:
10.1007/bf00505492
[Indexed for MEDLINE]

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