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J Pharmacol. 1982 Oct-Dec;13(4):515-24.

Action of clofoctol on bacterial cell wall synthesis.


Clofoctol inhibits in vivo cell wall synthesis of B. subtilis and gives rise to an accumulation of UDP-N-acetyl-muramyl pentapeptide. However, in vitro peptidoglycan synthesis using a particulate membrane preparation is not inhibited by clofoctol. These results suggest that clofoctol does not inhibit a specific enzyme of the cell wall synthesis, and that the inhibition of the cell wall synthesis might be a secondary effect due to a disturbance of the cytoplasmic membrane.

[Indexed for MEDLINE]

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