Abstract
A novel antibiotic, prothracarcin was isolated from the culture broth of Streptomyces umbrosus subsp. raffinophilus DO-62. The antibiotic has the molecular formula of C14H14N2O and belongs to the pyrrolo [1,4]benzodiazepine antibiotics. Its structure has been elucidated by mass and NMR spectra. It is active against Gram-positive and Gram-negative bacteria and experimental murine tumor sarcoma 180 and leukemia P388.
MeSH terms
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Animals
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Antibiotics, Antineoplastic / isolation & purification*
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Antibiotics, Antineoplastic / pharmacology
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Antibiotics, Antineoplastic / therapeutic use
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Benzodiazepines / isolation & purification
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Benzodiazepines / pharmacology
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Benzodiazepines / therapeutic use
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Chemical Phenomena
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Chemistry
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Fermentation
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Mice
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Neoplasms, Experimental / drug therapy
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Streptomyces / classification
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Streptomyces / metabolism*
Substances
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Antibiotics, Antineoplastic
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Benzodiazepines
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prothracarcin