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Vopr Onkol. 1982;28(7):28-34.

[Comparative study of 2 combined treatment regimens in stage-III to -IV ovarian cancer].

[Article in Russian]


The results of the treatment of 75 patients with ovarian carcinoma of epithelial origin are reported. The authors give a randomised clinical comparison of the efficacy of two schemes of complex treatment of 54 patients with ascitic ovarian carcinoma and 21 patients with non-ascitic ovarian carcinoma. The first scheme included cytoxan chemotherapy plus surgery plus polychemotherapy (25 patients); the second--surgery plus polychemotherapy (29 patients). Patients with non-ascitic carcinoma (21) received the second type of treatment. Polychemotherapy consisted of two alternating schedules: 5 fluorouracil plus cyclophosphamide and hexamethylamine plus cyclophosphamide after a two week interval. Better results were obtained in the group of patients treated surgically at the initial stage of treatment.

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