Abstract
The structure of the operator-binding domain of the lambda repressor has been determined at 3.2 A resolution. This domain contains an extended N-terminal arm and five alpha-helices. Model-building studies of the repressor-operator complex suggest that alpha-helices, especially the N-terminal parts of these helices, may provide a useful surface for protein-DNA interactions.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Amino Acid Sequence
-
Crystallography
-
DNA, Bacterial / metabolism*
-
DNA-Binding Proteins*
-
Models, Molecular
-
Nucleic Acid Conformation
-
Operon
-
Peptide Fragments / metabolism
-
Protein Conformation
-
Repressor Proteins / metabolism*
-
Transcription Factors / metabolism*
-
Viral Proteins
-
Viral Regulatory and Accessory Proteins
Substances
-
DNA, Bacterial
-
DNA-Binding Proteins
-
Peptide Fragments
-
Repressor Proteins
-
Transcription Factors
-
Viral Proteins
-
Viral Regulatory and Accessory Proteins
-
phage repressor proteins