The operator-binding domain of lambda repressor: structure and DNA recognition

Nature. 1982 Jul 29;298(5873):443-7. doi: 10.1038/298443a0.

Abstract

The structure of the operator-binding domain of the lambda repressor has been determined at 3.2 A resolution. This domain contains an extended N-terminal arm and five alpha-helices. Model-building studies of the repressor-operator complex suggest that alpha-helices, especially the N-terminal parts of these helices, may provide a useful surface for protein-DNA interactions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Crystallography
  • DNA, Bacterial / metabolism*
  • DNA-Binding Proteins*
  • Models, Molecular
  • Nucleic Acid Conformation
  • Operon
  • Peptide Fragments / metabolism
  • Protein Conformation
  • Repressor Proteins / metabolism*
  • Transcription Factors / metabolism*
  • Viral Proteins
  • Viral Regulatory and Accessory Proteins

Substances

  • DNA, Bacterial
  • DNA-Binding Proteins
  • Peptide Fragments
  • Repressor Proteins
  • Transcription Factors
  • Viral Proteins
  • Viral Regulatory and Accessory Proteins
  • phage repressor proteins