Ethylenediamine as a specific releasing agent of gamma-aminobutyric acid in rat striatal slices

J Neurochem. 1982 Apr;38(4):1168-9. doi: 10.1111/j.1471-4159.1982.tb05366.x.

Abstract

Following incubation with [14C]gamma-aminobutyric acid (GABA) or [3H]dopamine, slices of rat striatum were superfused with media containing 36 mM K+ or ethylenediamine (EDA), 1 or 5 mM. Both K+ and EDA induced a release being largely Ca2+-dependent, while the EDA-induced release was not. Whereas K+ also evoked a Ca2+-dependent release of [3H]dopamine, EDA evoked no release of dopamine. EDA may therefore have potential as a specific GABA releasing agent.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Corpus Striatum / drug effects
  • Corpus Striatum / metabolism*
  • Ethylenediamines / pharmacology*
  • In Vitro Techniques
  • Kinetics
  • Mice
  • Potassium / pharmacology
  • Rats
  • Rats, Inbred Strains
  • gamma-Aminobutyric Acid / metabolism*

Substances

  • Ethylenediamines
  • gamma-Aminobutyric Acid
  • ethylenediamine
  • Potassium