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Br J Pharmacol. 1982 Apr;75(4):605-12.

The effect of taurine on high potassium-and noradrenaline-induced contraction in rabbit ear artery.

Abstract

1 Intraluminal administration of taurine (40 mM) did not affect the contractile tone of rabbit isolated ear artery 2 Taurine (10-80 mM) exerted a powerful concentration-dependent, vasodilator action in arteries contracted with high potassium medium. 3 In the same experimental conditions, the taurine analogues beta-alanine and homotaurine, had no effect. 4 Taurine (40-80 mM) did not affect in a significant manner the tonic component of the noradrenaline (5x10(-6 M)-induced contraction. 5 When noradrenaline (5x10(-6M) was followed by the administration of high potassium medium a further increase in intraluminal pressure was observed. Under these conditions taurine (40 mM) reversed specifically the component due to the high potassium medium.

PMID:
7066608
PMCID:
PMC2071529
[Indexed for MEDLINE]
Free PMC Article
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